Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
产品简介
| Species | Human |
| Protein Construction | | His | GDF15 (Ala197-Ile308)Accession # Q99988-1 | | N-term | C-term |
|
| Purity | > 95% as determined by Bis-Tris PAGE |
| Endotoxin Level | Less than 1EU per μg by the LAL method. |
| Biological Activity | Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch. |
| Expression System | E.coli |
| Theoretical Molecular Weight | 13.5 kDa |
| Apparent Molecular Weight | The protein migrates to 15-16 kDa based on Bis-Tris PAGE result. |
| Formulation | Lyophilized from 0.22μm filtered solution in 50mM HAc (pH 2.9). |
| Reconstitution | Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9). |
| Storage & Stability | Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles. |